molecular disease sentence in Hindi
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- Treatment monitoring and identification of molecular disease mechanisms may be facilitated by this biomarker.
- This discovery of what Pauling came to call a " molecular disease " was revolutionary.
- This was the first molecular disease characterized.
- The molecular disease concept put forward in the 1949 paper also became the basis for Linus Pauling's view of evolution.
- The paper introduced the concept of a " molecular disease ", and is considered a major impetus to the development of molecular medicine.
- His discovery of sickle cell anemia as a " molecular disease " opened the way toward examining genetically acquired mutations at a molecular level.
- Since the early 1990s, a new class of molecular disease has been characterized based upon the presence of unstable and abnormal expansions of DNA-triplets ( trinucleotides ).
- In November 1949, Pauling, Harvey Itano, S . J . Singer and Ibert Wells published " Sickle Cell Anemia, a Molecular Disease " in the journal " Science ".
- As WHIM syndrome is a molecular disease arising from gain-of-function mutations in CXCR4, preclinical studies identified plerixafor, a specific CXCR4 antagonist, as a potential mechanism-based therapeutic for the disease.
- He also advocated eugenic policies, such as marking all who carry the sickle cell trait and other molecular disease genes, to reduce the number of children born with genetic diseases.
- Dr . Bryan Brewer, chief of the molecular disease branch at the National Heart, Lung and Blood Institute, said, " No one has ever seen anything like this in this amount of time ."
- This was introduced in November 1949, with the seminal paper, " Sickle Cell Anemia, a Molecular Disease ", in " Science " magazine, Linus Pauling, Harvey Itano and their collaborators laid the groundwork for establishing the field of molecular medicine.
- Pauling reinterpreted the large body of research on vitamin C based on comparative studies of the biochemical genetics of vitamin C synthesis in different species, as well his own theories about " molecular disease " and recent developments in molecular evolution.
- The book characterizes the inability of humans and some other animals to produce vitamin C in terms of evolution and Pauling's concept of " molecular disease " ( first articulated in his 1949 study, " Sickle Cell Anemia, a Molecular Disease " ).
- The book characterizes the inability of humans and some other animals to produce vitamin C in terms of evolution and Pauling's concept of " molecular disease " ( first articulated in his 1949 study, " Sickle Cell Anemia, a Molecular Disease " ).
- He worked as a postdoctoral fellow in the lab of Linus Pauling at Caltech during 1947-1948, where he, along with Harvey Itano, co-discovered the basis of abnormal hemoglobin in sickle-cell anemia, reported in the famous paper " Sickle Cell Anemia, a Molecular Disease ".
- His work in establishing the field of molecular biology; his studies of hemoglobin led to the classification of sickle cell anemia as a molecular disease . " The other scientists on this sheet of stamps included Gerty Cori, biochemist, Edwin Hubble, astronomer, and John Bardeen, physicist.
- In collaboration with Linus Pauling, Itano used electrophoresis to demonstrate the difference between normal hemoglobin and sickle cell hemoglobin; their 1949 paper " Sickle Cell Anemia, a Molecular Disease " ( coauthored also with S . J . Singer and Ibert C . Wells ) was a landmark in both molecular medicine and protein electrophoresis.
- "The study reported the drug decreased the plaque significantly, " said Dr . H . Bryan Brewer Jr ., the chief for the molecular disease branch at the National Heart, Lung and Blood Institute . " The interesting fact is that it takes years and years to develop hardening of the arteries-and within six weeks of using this drug, you see a significant change ."
- Pauling argues that the loss of vitamin C synthesis first arose as a molecular disease, because of a genetic mutation that resulted in the loss of the biochemical capacity to make the vitamin, but because diets of the primate ancestors of humans consisted of high levels of vitamin C from plant sources, the loss of that biochemical mechanism was not harmful and may have even been beneficial.
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